Tae Hyun Kim

Tae Hyun Kim

  • Assistant Professor of Avian Biology
  • Dorothy Foehr and J. Lloyd Huck Early Career Chair of Avian Transgenic Biology, Huck Institutes of Life Sciences
317 Animal, Veterinary and Biomedical Sciences Building
University Park, PA 16802

Areas of Expertise

  • Functional Genomics
  • Genome Editing
  • Avian Genetic Engineering

Education

  • Ph.D. Genetics, University of California, Davis (2019)
  • M.S. Animal Science, Seoul National University (2007)
  • B.S. Animal Science, Seoul National University (2005)

Research Interest

  • Develop in vitro/in vivo avian model system using CRISPR based genome editing tools.
  • Identify candidate genes and pathways associated with poultry economic traits using functional genomics approach.
  • Understand the genomic networks and molecular/cellular mechanisms of host-pathogen interaction against avian influenza virus.

Professional Experience

USDA-NIFA-AFRI-EWD postdoctoral fellow, University of California, Davis (2019-20)
USDA-NIFA-AFRI-ELI predoctoral fellow, University of California, Davis (2017-19)
Research associate, WCU Biomodulation, Seoul National University (2011-12)
Research associate, Avicore Biotechnology Institute (2007-11)

Graduate Programs

Publications

Han JH, Lee HJ, Kim TH. Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation. Frontiers in Genome Editing. 2023 doi.org/10.3389/fgeed.2023.1269115

Chapman B, Han JH, Lee HJ, Ruud I, Kim TH. Targeted modulation of chicken genes in vitro using CRISPRa and CRISPRi toolkit. Genes (Basel). 2023 doi:10.3390/genes14040906

Choi HJ, Jung KM, Rengaraj D, Lee KY, Yoo E, Kim TH & Han JY. Single-cell RNA sequencing of mitotic-arrested prospermatogonia with DAZL::GFP chickens and revealing unique epigenetic reprogramming of chickens. Journal of Animal Science and Biotechnology. 2022 doi:10.1186/s40104-022-00712-4

Kim TH, Kern C, Zhou H. Knockout of IRF7 highlights its modulator function of host response against avian influenza virus and the involvement of MAPK and TOR signaling pathways in chicken. Genes (Basel). 2020 doi:10.3390/genes11040385

Choi S, Kim TH, Hong M, Park TS, Lee H, Lee S. Transcriptomic alterations induced by aflatoxin B1 and ochratoxin A in LMH cell line. Poultry Science. 2020 doi:10.1016/j.psj.2020.05.058

Kim TH, Zhou H. Overexpression of chicken IRF7 increased viral replication and programmed cell death to the avian influenza virus infection through TGF-beta/FoxO signaling axis in DF-1. Frontiers in Genetics. 2018 doi:10.3389/fgene.2018.00415

Kim TH, Zhou H. Functional analysis of chicken IRF7 in response to dsRNA analog poly(I:C) by integrating overexpression and knockdown. PLoS One. 2015 doi:10.1371/journal.pone.0133450

Jang HJ, Lee MO, Kim S, Kim TH, Kim SK, Song G, Womack JE, Han JY. Biallelic expression of the L-arginine:glycine amidinotransferase gene with different methylation status between male and female primordial germ cells in chickens. Poult Sci. 2013 doi:10.3382/ps.2012-02538

Kim TH, Yun TW, Rengaraj D, Lee SI, Lim SM, Seo HW, Park TS, Han JY. Conserved functional characteristics of the PIWI family members in chicken germ cell lineage. Theriogenology. 2012 doi:10.1016/j.theriogenology.2012.07.019

Rengaraj D, Lee BR, Choi JW, Lee SI, Seo HW, Kim TH, Choi HJ, Song G, Han JY. Gene pathways and cell cycle-related genes in cultured avian primordial germ cells. Poult Sci. 2012 doi:10.3382/ps.2012-02279

Rengaraj D, Lee SI, Yoo M, Kim TH, Song G, Han JY. Expression and knockdown analysis of glucose phosphate isomerase in chicken primordial germ cells. Biol Reprod. 2012 doi:10.1095/biolreprod.112.101345

Park SH, Kim JN, Park TS, Lee SD, Kim TH, Han BK, Han JY. CpG methylation modulates tissue-specific expression of a transgene in chickens. Theriogenology. 2010 doi:10.1016/j.theriogenology.2010.04.005

Jung JG, Lee YM, Kim JN, Kim TM, Shin JH, Kim TH, Lim JM, Han JY. The reversible developmental unipotency of germ cells in chicken. Reproduction. 2010 doi:10.1530/REP-09-0265