Tae Hyun Kim

Tae Hyun Kim

  • Assistant Professor of Avian Biology
  • Dorothy Foehr and J. Lloyd Huck Early Career Chair of Avian Transgenic Biology, Huck Institutes of Life Sciences
317 Animal, Veterinary and Biomedical Sciences Building
University Park, PA 16802

Areas of Expertise

  • Functional Genomics
  • Genome Editing
  • Avian Genetic Engineering

Education

  • Ph.D. Genetics, University of California, Davis (2019)
  • M.S. Animal Science, Seoul National University (2007)
  • B.S. Animal Science, Seoul National University (2005)

Research Interest

  • Develop in vitro/in vivo avian model system using CRISPR based genome editing tools.
  • Identify candidate genes and pathways associated with poultry economic traits using functional genomics approach.
  • Understand the genomic networks and molecular/cellular mechanisms of host-pathogen interaction against avian influenza virus.

Professional Experience

USDA-NIFA-AFRI-EWD postdoctoral fellow, University of California, Davis (2019-20)
USDA-NIFA-AFRI-ELI predoctoral fellow, University of California, Davis (2017-19)
Research associate, WCU Biomodulation, Seoul National University (2011-12)
Research associate, Avicore Biotechnology Institute (2007-11)

Graduate Programs

  • Animal Science
  • Bioinformatics and Genomics
  • Molecular, Cellular, and Integrative Biosciences

Publications

Zhou H, McCarthy FM, Kim TH, Warren W, Zhang G. Emerging technologies in poultry genomics: Unlocking innovation for the future of sustainable production. Poultry Sci. 2025; DOI: 10.1016/j.psj.2025.106240

Kim J, Han JH, Kim M, Schmidt G, Cho E, Lee JH, Kim TH. From GWAS signal to function: Targeted CRISPR activation enables functional characterization of non-coding SNPs in chickens. Front. Genome Ed. 2025; DOI: 10.3389/fgeed.2025.1662152

Lee HJ, Han JH, Chapman B, Jung KM, Rudd I, Han JY, Kim TH. A comprehensive transcriptional profiling of developing gonads reveals the role of TGFβ signaling in female gonadal asymmetry in chickens. Poultry Sci. 2025; DOI: 10.1016/j.psj.2025.104932

Weaver EA, Connolly NP, Kim TH, Ramachandran R. Metformin alters liver metabolism to sustain egg production in reproductively aging broiler breeder hens. Biol. Reprod. 2025; DOI: 10.1093/biolre/ioaf072

Lim SJ, Shin S, Kim TH*, Lee SI*. Euphorbia hypericifolia attenuates citrinin-induced oxidative stress and maintains tight junction integrity in porcine intestinal epithelial cells. Int. J. Mol. Sci. 2025; DOI: 10.3390/ijms26167773

Yoon JW, Shin S, Kim TH*, Lee SI*. Integrated transcriptome and metabolome analysis of the porcine small intestine during weaning. Genes (Basel). 2025; DOI: 10.3390/genes16070727

Lee CH, Shin S, Kim TH*, Lee SI*. Nymphoides peltata alleviates patulin-induced glutamine metabolic stress and epithelial toxicity in small intestinal epithelial cells. Toxins 2025; DOI: 10.3390/toxins17070337

Kang TH, Shin SS, Kim TH, Lee SI. Ivangustin alleviates deoxynivalenol-induced apoptosis by regulating FOXO3a translocation in porcine intestinal epithelial cells. Toxins DOI: 10.3390/toxins17040174

Han JH, Lee HJ, Kim TH. Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation. Front. Genome Ed. 2023; DOI: 10.3389/fgeed.2023.1269115

Chapman B#, Han JH#, Lee HJ, Rudd I, Kim TH. Targeted modulation of chicken genes in vitro using CRISPRa and CRISPRi toolkit. Genes (Basel). 2023; DOI: 10.3390/genes14040906

Choi HJ, Jung KM, Rengaraj D, Lee KY, Yoo E, Kim TH, Han JY. Single-cell RNA sequencing of mitotic-arrested prospermatogonia with DAZL::GFP chickens reveals unique epigenetic reprogramming. J. Anim. Sci. Biotechnol. 2022; DOI: 10.1186/s40104-022-00712-4

Kim TH, Kern C, Zhou H. Knockout of IRF7 highlights its modulatory function in host response against avian influenza virus and the involvement of MAPK and TOR signaling pathways in chickens. Genes (Basel). 2020; DOI: 10.3390/genes11040385

Choi S, Kim TH, Hong M, Park TS, Lee H, Lee S. Transcriptomic alterations induced by aflatoxin B1 and ochratoxin A in LMH cell line. Poultry Sci. 2020; DOI: 10.1016/j.psj.2020.05.058

Kim TH, Zhou H. Overexpression of chicken IRF7 increases viral replication and programmed cell death to avian influenza virus infection through TGF-β/FoxO signaling axis in DF-1. Front. Genet. 2018; DOI: 10.3389/fgene.2018.00415

Kim TH, Zhou H. Functional analysis of chicken IRF7 in response to dsRNA analog poly(I:C) by integrating overexpression and knockdown. PLoS One 2015; DOI: 10.1371/journal.pone.0133450

Jang HJ, Lee MO, Kim S, Kim TH, Kim SK, Song G, Womack JE, Han JY. Biallelic expression of the L-arginine:glycine amidinotransferase gene with different methylation status between male and female primordial germ cells in chickens. Poultry Sci. 2013; DOI: 10.3382/ps.2012-02538

Kim TH, Yun TW, Rengaraj D, Lee SI, Lim SM, Seo HW, Park TS, Han JY. Conserved functional characteristics of the PIWI family members in chicken germ cell lineage. Theriogenology 2012; DOI: 10.1016/j.theriogenology.2012.07.019

Rengaraj D, Lee BR, Choi JW, Lee SI, Seo HW, Kim TH, Choi HJ, Song G, Han JY. Gene pathways and cell cycle-related genes in cultured avian primordial germ cells. 2012; DOI: 10.3382/ps.2012-02279

Rengaraj D, Lee SI, Yoo M, Kim TH, Song G, Han JY. Expression and knockdown analysis of glucose phosphate isomerase in chicken primordial germ cells. Biol. Reprod. 2012; DOI: 10.1095/biolreprod.112.101345

Park SH, Kim JN, Park TS, Lee SD, Kim TH, Han BK, Han JY. CpG methylation modulates tissue-specific expression of a transgene in chickens. Theriogenology 2010; DOI: 10.1016/j.theriogenology.2010.04.005

Jung JG, Lee YM, Kim JN, Kim TM, Shin JH, Kim TH, Lim JM, Han JY. The reversible developmental unipotency of germ cells in chicken. Reproduction 2010; DOI: 10.1530/REP-09-0265